Male, Age : 51-60 years old , Reason : MS Fatigue. Side Effects : None Review : I took aspirin for MS fatigue after reading a 2005 Mayo Clinic study which suggested 1300mg/day of aspirin could reduce MS fatigue. 1300mg/d is a relatively high dose for aspirin, but I gave it a try. Unfortunately it didn't work for me (few drugs are effective for MS fatigue). It's a shame it didn't work, because aspirin is a fairly safe drug, easily available and cheap.